کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065359 1580476 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Correlation of specialized CD16+ γδ T cells with disease course and severity in multiple sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Correlation of specialized CD16+ γδ T cells with disease course and severity in multiple sclerosis
چکیده انگلیسی

γδ T cells may be important innate immune system contributors to the immunopathogenesis of multiple sclerosis (MS), though the mechanisms are not yet fully understood. CD16 is a low affinity Fcγ receptor, an activation receptor for γδ T cells, and a mediator of cytotoxicity. In this study, we found that the percentage of CD16+ γδ T cells is elevated in MS patients compared with healthy controls. The increase is especially pronounced in patients with a progressive course of the disease, and the extent of this elevation shows a positive correlation with the time of disease progression and severity. In vitro cultured γδ T cells can be shown to upregulate the expression of CD16 in response to inflammatory cytokines such as IL-2 and -15, that have been shown to be elevated in progressive disease. These results suggest that CD16 expressing γδ T cells are somehow involved in the process of disease progression. Understanding more about these cells and their particular function in progressive vs. non-progressive disease could provide important clues to the mechanism of immune-mediated MS disease progression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 194, Issues 1–2, February 2008, Pages 147–152
نویسندگان
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