کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065388 1580472 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: A neuropathological study
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: A neuropathological study
چکیده انگلیسی

An immunological function has been proposed for the choroid plexus (CP). In multiple sclerosis (MS) brains, CPs show (immunohistochemistry to HLA-DR, CD3, CD20, CD68, VCAM-1, CD138) T lymphocytes in vessels and stroma, VCAM-1 expression on endothelia, intense HLA-DR immunostaining on cells in CP stroma, among CP epithelium and on epiplexus cells. CPs in control or amyotrophic lateral sclerosis brains do not show such inflammatory changes. Intense CP inflammation is observed in viral encephalitis. Changes in MS CPs suggest persisting immune activation, with intensity similar to acute encephalitis, even in MS phases in which neurodegeneration prevails. In MS, CPs could represent a site for lymphocyte entry in the CSF and for CSF antigens presentation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 199, Issues 1–2, 13 August 2008, Pages 133–141
نویسندگان
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