کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065411 | 1580474 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preventive and curative effects of cyclophosphamide in an animal model of Guillain Barrè syndrome
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Preventive and curative effects of cyclophosphamide in an animal model of Guillain Barrè syndrome Preventive and curative effects of cyclophosphamide in an animal model of Guillain Barrè syndrome](/preview/png/3065411.png)
چکیده انگلیسی
The immunosuppressive agent cyclophosphamide (CY) was tested in rat experimental allergic neuritis (EAN), a preclinical model of Guillain Barrè syndrome (GBS). CY prophylaxis (day 0 and 14 post-immunization [p.i.]) effectively prevents clinical and histological signs of EAN and also reduces the cytokine and the NF-κB p65 expression in the nervous tissue. When administered therapeutically (day 14th p.i.) to rats with established disease CY only affects the clinical symptoms. Both the prophylactic and therapeutic treatment with CY reduced ex vivo antigen-specific T cell proliferative responses. These results warrant studies with CY in those cases of GBS resistant to conventional therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 196, Issues 1â2, 30 May 2008, Pages 107-115
Journal: Journal of Neuroimmunology - Volume 196, Issues 1â2, 30 May 2008, Pages 107-115
نویسندگان
Katia Mangano, Gabriele Dati, Cinzia Quattrocchi, Lidia Proietti, Clorinda Mazzarino, Roberto Di Marco, Klaus Bendtzen, Beatrice Greco, Paola Zaratin, Ferdinando Nicoletti,