کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065419 | 1580474 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF](/preview/png/3065419.png)
چکیده انگلیسی
MS is thought to be mediated by CD4+ T-helper cells. To investigate the importance of CD8+ cytotoxic T-cells in MS we analyzed peripheral blood T-cells by DNA microarray, and plasma and CSF levels of granzymes from MS patients and controls. Cytotoxic gene expression was decreased in peripheral T-cells from RRMS patients whereas plasma levels of granzymes were unchanged. However, granzyme levels were elevated in the CSF of RRMS patients at relapse compared with controls and remission. Thus, CD8+ T-cell-mediated cytotoxicity is confined to the CSF/CNS compartment in RRMS patients and may be involved in the immunopathogenesis of clinical relapses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 196, Issues 1–2, 30 May 2008, Pages 159–165
Journal: Journal of Neuroimmunology - Volume 196, Issues 1–2, 30 May 2008, Pages 159–165
نویسندگان
Clas Malmeström, Jan Lycke, Sara Haghighi, Oluf Andersen, Lena Carlsson, Hans Wadenvik, Bob Olsson,