کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065440 1580490 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients
چکیده انگلیسی

Effects of B cell depletion by rituximab, a monoclonal antibody to CD20, were studied in patients with relapsing MS that had not responded optimally to standard immunomodulatory therapies. Flow cytometry demonstrated reduced cerebrospinal fluid (CSF) B cells and T cells in most patients at 6 months post-treatment. ELISAs demonstrated modest reductions in serum antibodies to myelin oligodendrocyte glycoprotein and myelin basic protein in some subjects. Beta-interferon neutralizing antibodies were reduced in three subjects, but developed anew after treatment in three others, suggesting caution in considering rituximab as a means to eliminate NABs. In summary, rituximab depleted B cells from CSF at 24 weeks after initial treatment, and this B cell depletion was associated with a reduction in CSF T cells as well.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 180, Issues 1–2, November 2006, Pages 63–70
نویسندگان
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