کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065489 1580481 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IFNβ bioavailability in multiple sclerosis patients: MxA versus antibody-detecting assays
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
IFNβ bioavailability in multiple sclerosis patients: MxA versus antibody-detecting assays
چکیده انگلیسی

Anti-IFNβ antibodies are related to IFNβ bioavailability loss in multiple sclerosis. We investigated the reliability of radioimmunoprecipitation and cytopathic assays in detecting binding (BAbs) and neutralizing (NAbs) antibodies and the correlation of these antibodies to MxA mRNA production. Eleven percent of IFNβ-treated patients showed a lack of MxA induction, with an inverse correlation between MxA mRNA and the presence of BAbs and NAbs. Some patients had contemporary MxA induction in the presence of high NAb titres, thus calling into question the reliability of cytopathic assay. Since anti-IFNβ antibodies well correlated with MxA induction loss, MxA assay is an appropriate test to determine IFNβ bioavailability.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 189, Issues 1–2, September 2007, Pages 102–110
نویسندگان
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