کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065521 | 1580475 | 2008 | 14 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis](/preview/png/3065521.png)
To investigate CD8+ regulatory T cell influence on multiple sclerosis development, peripheral blood and cerebrospinal fluid (CSF) CD8+ T cell clones (TCCs) recognizing MBP83–102 and MOG63–87-specific CD4+ T cells were isolated from 20 patients during acute exacerbations, 15 in remission and 15 controls. Blood and CSF CD8+ regulatory TCC cloning frequency decreased more during exacerbations than remissions or controls. Target cell pre-activation significantly enhanced CD8+ T granule-mediated cell killing of CD4+ targets, and was restricted by HLA-E. During exacerbations, killer-inhibitory receptor CD94/NKG2A expression was significantly higher in CD8+ TCCs, limiting their cytotoxic activity. Moreover, IL-15 and IFN-γ significantly increased CD94 and NKG2A expression. These data provide evidence that CD94/NKG2A receptors play an important role in regulating T cell activity during the course of MS.
Journal: Journal of Neuroimmunology - Volume 195, Issues 1–2, March 2008, Pages 121–134