کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065593 1580485 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proteome analysis of cerebrospinal fluid in Guillain–Barré syndrome (GBS)
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Proteome analysis of cerebrospinal fluid in Guillain–Barré syndrome (GBS)
چکیده انگلیسی

We used two-dimensional difference in-gel electrophoresis (2-D-DIGE) for proteome analysis of cerebrospinal fluid (CSF) in Guillain–Barré syndrome (GBS). Spots showing > 2-fold difference between GBS and controls were analysed using MALDI-TOF mass spectrometry.Proteins that were up-regulated in GBS included haptoglobin, serine/threonine kinase 10, α-1-antitrypsin, SNC73, alpha II spectrin, IgG kappa chain and cathepsin D preprotein, while transferrin, caldesmon, GALT, human heat shock protein 70, amyloidosis patient HL-heart-peptide 127aa and transthyretin were down-regulated. Some of these proteins are reported in CSF of GBS for the first time. Accordingly, the 2-D-DIGE technology may be useful to identify disease-specific proteins in patients with GBS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 185, Issues 1–2, April 2007, Pages 190–194
نویسندگان
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