کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065717 1580489 2006 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
5-HT1B receptors play a prominent role in the proliferation of T-lymphocytes
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
5-HT1B receptors play a prominent role in the proliferation of T-lymphocytes
چکیده انگلیسی

Serotonin plays a role in T cell activation, but there is no clear consensus of which of the 14 serotonergic receptors control this activations pathway. We have used a broad range of serotonergic receptor antagonists to define the functional involvement of these receptors governing the proliferation of primary T cells as well as in T cell lines. Our data shows that antagonism of the 5-HT1B receptor inhibits the proliferation of both human and murine primary helper T cells and of human helper T cell lines. As a whole, our data suggest that other serotonergic receptors may contribute to the proliferative signals, but the 5-HT1B receptor plays the most dominant role.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 181, Issues 1–2, December 2006, Pages 68–81
نویسندگان
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