کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065729 | 1580489 | 2006 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of pyruvate kinase as an antigen associated with Tourette syndrome
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification of pyruvate kinase as an antigen associated with Tourette syndrome Identification of pyruvate kinase as an antigen associated with Tourette syndrome](/preview/png/3065729.png)
چکیده انگلیسی
Immune responses to β-hemolytic streptococcal infections are hypothesized to trigger tic disorders and early-onset obsessive-compulsive disorder (OCD) in some pediatric populations. Here we identify the M1 isoform of the glycolytic enzyme, pyruvate kinase (PK) as an autoimmune target in Tourette syndrome and associated disorders. Antibodies to PK reacted strongly with surface antigens of infectious strains of streptococcus, and antibodies to streptococcal M proteins reacted with PK. Moreover, immunoreactivity to PK in patients with exacerbated symptoms who had recently acquired a streptococcal infection was 7-fold higher compared to patients with exacerbated symptoms and no evidence of a streptococcal infection. These data suggest that PK can function as an autoimmune target and that this immunoreactivity may be associated with Tourette syndrome, OCD, and associated disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 181, Issues 1â2, December 2006, Pages 165-176
Journal: Journal of Neuroimmunology - Volume 181, Issues 1â2, December 2006, Pages 165-176
نویسندگان
Janice W. Kansy, Liliya Katsovich, Kevin S. McIver, Jennifer Pick, John B. Zabriskie, Paul J. Lombroso, James F. Leckman, James A. Bibb,