کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065757 1580486 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of the SgIGSF/Necl-2 adhesion molecule in degranulation of mesenteric mast cells
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Involvement of the SgIGSF/Necl-2 adhesion molecule in degranulation of mesenteric mast cells
چکیده انگلیسی

Spermatogenic immunoglobulin superfamily (SgIGSF) expressed on nerve and mast cells, binds homophilically between both in culture. In the steady-state mesentery of mice, the proportion of morphologically degranulating mast cells was approximately 20%, and it increased nearly two-fold when the mesenteric nerve root was stimulated electrically. In contrast, there was no significant increase detectable in the mesentery of MITF-mutants, from which bone marrow-derived cultured mast cells (BMMCs) lack SgIGSF. BMMCs from SgIGSF-knockout mice transplanted to the mesentery of mast cell-deficient W/Wv mice did not degranulate in response to the mesenteric nerve stimulation, whereas transfection with SgIGSF cDNA restored those responses. SgIGSF appeared to promote communication between nerves and mast cells in the murine mesentery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 184, Issues 1–2, March 2007, Pages 209–213
نویسندگان
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