کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065802 | 1580487 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of chronic stress on the immune response to oral human serum albumin-conjugated starch microparticles in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of chronic stress on the immune response to oral human serum albumin-conjugated starch microparticles in rats Effects of chronic stress on the immune response to oral human serum albumin-conjugated starch microparticles in rats](/preview/png/3065802.png)
چکیده انگلیسی
Uptake of antigens and bacteria over the follicle-associated epithelium (FAE) is increased after chronic psychological stress. We investigated whether stress affects the immune response to particle-conjugated antigens taken up via the FAE. Rats were submitted to two 10-day periods of water avoidance stress and orally immunized during these periods. Stressed immunized rats displayed altered cell populations and a Th1-skewed immune response within the lymphoid follicles, together with enhanced delayed-type hypersensitivity. We conclude that chronic stress affects the cell-mediated immune response after oral immunization, which may have implications for the understanding of allergic and autoimmune diseases and development of oral vaccines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 183, Issues 1–2, February 2007, Pages 33–42
Journal: Journal of Neuroimmunology - Volume 183, Issues 1–2, February 2007, Pages 33–42
نویسندگان
Åsa V. Keita, Linda Stertman, Yi-Qian Sun, Agneta Larhed, Ingvar Sjöholm, Johan D. Söderholm,