کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065919 1580493 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intrathecal cytokines in spinal cord schistosomiasis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Intrathecal cytokines in spinal cord schistosomiasis
چکیده انگلیسی

We investigate the cytokine profile in the cerebrospinal fluid (CSF) and serum of patients with spinal cord schistosomiasis (SCS). Increased levels of IL-1β, IL-4, IL-6 and IL-10 and low concentrations of TNF-α and IFN-γ were observed in both CSF and serum. CSF showed higher levels of IL-4 and IL-6 when compared to the paired serum samples. A negative correlation between the concentrations of IL-10 and IFN-γ was observed in the CSF. These findings suggest an inflammatory as well as a skewed type-2 immune response that probably occur both locally and systemically and may be involved in the pathogenesis of SCS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 177, Issues 1–2, August 2006, Pages 136–141
نویسندگان
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