کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065929 1580493 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Isolation and culture of microvascular endothelial cells from murine spinal cord
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Isolation and culture of microvascular endothelial cells from murine spinal cord
چکیده انگلیسی

The isolation and culture of spinal cord microvascular endothelial cells (SCMEC), which form the blood–spinal cord barrier (BSCB), is described. Though morphologically similar to brain microvacular endothelial cells (BMEC) that form the blood–brain barrier (BBB), SCMEC express reduced amounts of several prominent BBB proteins, including tight junction-associated proteins ZO-1 and occludin, adherens junction-associated proteins β-catenin and VE-cadherin, and the efflux transporter P-glycoprotein. These distinguishing features may reflect more widespread differences between the BBB and BSCB that impact physiological and pathophysiological processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 177, Issues 1–2, August 2006, Pages 209–214
نویسندگان
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