کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065960 1580491 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
5HT4 agonists inhibit interferon-γ-induced MHC class II and B7 costimulatory molecules expression on cultured astrocytes
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
5HT4 agonists inhibit interferon-γ-induced MHC class II and B7 costimulatory molecules expression on cultured astrocytes
چکیده انگلیسی

A failure of tight control of MHC class II expression on astrocytes may play a role in the development of autoimmune responses in multiple sclerosis. The 5-HT4 serotonin receptor agonists cisapride and prucalopride, at concentrations between 10− 10 M and 10− 8 M, reduced interferon-γ-induced MHC class II immunostaining in cultured astrocytes derived from newborn Wistar rats by approximately 50–60%. The magnitude of MHC class II inhibition by 5-HT4 agonists was comparable to that of interferon-β. The α1-adrenergic receptor agonist phenylephrine was without effect. Cisapride (10− 9 M) also prevented interferon-γ-induced B7-1 and B7-2 immunostaining. Our results suggest that 5-HT4 agonists may have therapeutic potential in multiple sclerosis by inhibiting the up-regulation of immune responsiveness of astrocytes in the central nervous system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 179, Issues 1–2, October 2006, Pages 191–195
نویسندگان
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