کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3066001 1580496 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunolocalization and activation of nuclear factor-κB in the sciatic nerves of rats with experimental autoimmune neuritis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Immunolocalization and activation of nuclear factor-κB in the sciatic nerves of rats with experimental autoimmune neuritis
چکیده انگلیسی

Recent data support an important role played by nuclear factor kappa B (NF-κB) in peripheral neuropathies. We investigated expression and activation of NF-κB in experimental autoimmune neuritis (EAN) in rat sciatic nerves removed after 7, 14 and 21 days after immunization. Immunoreactivity for the activated form of NF-κB was found in the nuclei of T cells and macrophages at days 14 and 21, and also in the nuclei of few Schwann cells and of vascular endothelial cells at all time points, especially during the peak stage. Western blot showed a single band corresponding to 65 kDa in all EAN animals. NF-κB DNA-binding activity was revealed by electrophoretic mobility shift assay. Our results support NF-κB activation in EAN during the induction stage as well as in the disease remission.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 174, Issues 1–2, May 2006, Pages 32–38
نویسندگان
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