کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3066105 | 1580495 | 2006 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Neuroprotection induced by mucosal tolerance is epitope-dependent: Conflicting effects in different strains Neuroprotection induced by mucosal tolerance is epitope-dependent: Conflicting effects in different strains](/preview/png/3066105.png)
The ability to cope with ongoing neurodegeneration after injury to the central nervous system of mammals differs among strains and depends in part on the animal's ability to manifest a T-cell-mediated protective response. After CNS injury, strain-related differences were observed. Moreover, the post-injury effect of naturally occurring regulatory CD4+CD25+ T cells was found to differ in different strains. In this study, using partially injured optic nerves of Balb/c/OLA and C57BL/6J mice as models, we observed strain-related differences in the T-cell-mediated protection obtained by antigens administered via the nasal route. Active immunization with myelin-related antigens emulsified in complete Freund's adjuvant had a beneficial effect on both strains, whereas mucosal administration of the same antigens was destructive in mice of the Balb/c/OLA strain but protective in C57BL/6J mice.
Journal: Journal of Neuroimmunology - Volume 175, Issues 1–2, June 2006, Pages 31–38