کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3066116 1580495 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
(5R)-5-Hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
(5R)-5-Hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation
چکیده انگلیسی

A novel triptolide derivative (5R)-5-hydroxytriptolide (LLDT-8) has been shown to have potent immunosuppressive activities. Here LLDT-8 was evaluated in experimental autoimmune encephalomyelitis (EAE), the model of multiple sclerosis (MS). LLDT-8 reduced the incidence and severity of EAE, which was associated with the inhibition of the MOG 35–55 lymphocyte recall response, anti-MOG 35–55 T cell responses, interleukin (IL)-2 and interferon (IFN)-γ production. In vitro, LLDT-8 inhibited primary T cells proliferation, division, IL-2 and IFN-γ production stimulated with anti-CD3/28. These findings highlight the fact that LLDT-8 prevents EAE by suppressing T cell proliferation and activation, with a potential for treatment of MS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 175, Issues 1–2, June 2006, Pages 142–151
نویسندگان
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