کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3066120 1580495 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IL-6 and CCL2 levels in CSF are associated with the clinical course of MS: Implications for their possible immunopathogenic roles
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
IL-6 and CCL2 levels in CSF are associated with the clinical course of MS: Implications for their possible immunopathogenic roles
چکیده انگلیسی

Biological markers would provide valuable tools for tracking disease activity, immunopathological processes or therapeutic efficacy in MS. In this study we analysed a panel of Th1/Th2 cytokines and the chemokine CCL2 in serum and CSF from MS patients and healthy controls. Increased levels of IL-6 (p < 0.05) and decreased levels of CCL2 (p < 0.001), with the lowest levels during acute relapses, was found in CSF from patients with relapsing–remitting MS. CSF levels of CCL2 correlated with indices for intrathecal IgG production and the CSF level of the neurofilament light protein, a marker for axonal damage, indicating a immunopathogenic role for CCL2.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 175, Issues 1–2, June 2006, Pages 176–182
نویسندگان
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