کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3066145 | 1580499 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro Th2 deviation of myelin-specific peripheral blood lymphocytes from patients with multiple sclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In vitro Th2 deviation of myelin-specific peripheral blood lymphocytes from patients with multiple sclerosis In vitro Th2 deviation of myelin-specific peripheral blood lymphocytes from patients with multiple sclerosis](/preview/png/3066145.png)
چکیده انگلیسی
This study aimed at investigating if selective ex vivo immune deviation of myelin-specific cytokine secretion towards Th2 is possible in blood cells from patients with multiple sclerosis (MS). Interleukin (IL)-4 (Th2) and interferon-γ (Th1) secreting cells were recorded by ELISPOT in 13 MS patients. Deviation was successful in 10 patients. Interleukin-4 alone was most effective in inducing myelin-specific immune deviation in MS patients whereas IL-1 or IL-15 in combination with IL-4 did not improve the results. Further studies and improvements are needed before ex vivo immune deviation can be considered a potential treatment in patients with MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 171, Issues 1–2, February 2006, Pages 156–162
Journal: Journal of Neuroimmunology - Volume 171, Issues 1–2, February 2006, Pages 156–162
نویسندگان
E. Hallin, J. Mellergård, M. Vrethem, J. Ernerudh, C. Ekerfelt,