کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3066150 1580499 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
No association of leukemia inhibitory factor (LIF) DNA polymorphisms with multiple sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
No association of leukemia inhibitory factor (LIF) DNA polymorphisms with multiple sclerosis
چکیده انگلیسی

Neuropoietins such as leukemia inhibitory factor (LIF) have been shown to ameliorate experimental autoimmune encephalomyelitis (EAE) and promote oligodendrocyte survival in vivo. We tested whether two previously described LIF polymorphisms are associated with MS by genotyping these single nucleotide polymorphisms (SNPs) in a group of MS patients (n = 110), rheumatoid arthritis (RA) patients (n = 120) and healthy controls (HC, n = 109). Similar allele and genotype frequencies for both SNPs were found for all study groups. Furthermore, no associations with MS type or HLA-DR2 expression could be found. In summary, no association was found between the studied LIF DNA polymorphisms and the prevalence of MS indicating that these polymorphisms are not involved in determining disease susceptibility.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 171, Issues 1–2, February 2006, Pages 189–192
نویسندگان
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