کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3071969 1580925 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Local mechanical properties of white matter structures in the human brain
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Local mechanical properties of white matter structures in the human brain
چکیده انگلیسی


• MR elastography generates spatially resolved mechanical property maps of the brain.
• Mechanical properties of human corpus callosum and corona radiata are quantified.
• Structures are mechanically distinct and stiffer than white matter in general.
• Strong correlations exist between MRE and DTI properties within each structure.

The noninvasive measurement of the mechanical properties of brain tissue using magnetic resonance elastography (MRE) has emerged as a promising method for investigating neurological disorders. To date, brain MRE investigations have been limited to reporting global mechanical properties, though quantification of the stiffness of specific structures in the white matter architecture may be valuable in assessing the localized effects of disease. This paper reports the mechanical properties of the corpus callosum and corona radiata measured in healthy volunteers using MRE and atlas-based segmentation. Both structures were found to be significantly stiffer than overall white matter, with the corpus callosum exhibiting greater stiffness and less viscous damping than the corona radiata. Reliability of both local and global measures was assessed through repeated experiments, and the coefficient of variation for each measure was less than 10%. Mechanical properties within the corpus callosum and corona radiata demonstrated correlations with measures from diffusion tensor imaging pertaining to axonal microstructure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 79, 1 October 2013, Pages 145–152
نویسندگان
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