کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3072104 1188744 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The relationships between extent and microstructural properties of the midsagittal corpus callosum in human brain
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
The relationships between extent and microstructural properties of the midsagittal corpus callosum in human brain
چکیده انگلیسی

Recent quantitative analyses of the corpus callosum (CC) have tried to assess the interhemispheric connectivity. Based on histological results showing an expansion of callosal extent at the midsagittal plane, without fiber density alterations, callosal extent was interpreted as an index of interhemispheric connectivity. The microstructural properties of the CC have also been investigated extensively using diffusion tensor imaging, to assess interhemispheric connectivity. The relationships between axonal density and callosal extent need to be investigated to understand how these parameters reflect interhemispheric connectivity. We used a semi-automated CC segmentation scheme in T1-weighted magnetic resonance image and fractional anisotropy (FA) image, respectively. The parameterization method of the segmented CC was applied to 47 right-handed healthy adult subjects. The callosal extent and microstructural properties were measured using the callosal thickness and diffusion indices (FA, mean diffusivity, and axial and radial diffusivity), respectively. Our results revealed a correlation between callosal thickness and FA on the posterior body and isthmus of the CC, which suggests that these regions are more sensitive to fiber alterations than other regions. Based on this result, we suggest that both the extent of the CC and its microstructural properties should be considered together in the estimation of interhemispheric connectivity in healthy adult populations.

Research highlights
► The association between fiber density and callosal extent in healthy adult population.
► Fiber density may increase while callosal posterior body and isthmus areas expand.
► Extent and microstructural properties of CC in the interhemispheric connectivity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 56, Issue 1, 1 May 2011, Pages 174–184
نویسندگان
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