کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3072137 1188757 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Direct visualization of non-human primate subcortical nuclei with contrast-enhanced high field MRI
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Direct visualization of non-human primate subcortical nuclei with contrast-enhanced high field MRI
چکیده انگلیسی

Subcortical nuclei are increasingly targeted for deep brain stimulation (DBS) and for gene transfer to treat neurological and psychiatric disorders. For a successful outcome in patients, it is critical to place DBS electrodes or infuse viral vectors accurately within targeted nuclei. However current MRI approaches are still limited to localize brainstem and basal ganglia nuclei accurately. By combining ultra-high resolution structural MRI and contrast-enhanced MRI using iron oxide nanoparticles at high field (3 T and 7 T), we could precisely locate the subcortical nuclei, in particular the subthalamic nucleus in macaques, and validate this location by intracranial electrophysiological mapping. The present data pave the way to a clinical application.

Figure optionsDownload high-quality image (100 K)Download as PowerPoint slideResearch highlights
► Identification of the subthalamic nucleus in the non-human primate using MRI at 3T and 7T.
► Contrast enhancement with P904, an ultra-small superparamagnetic iron oxide particle.
► Electrophysiological mapping confirmation of MRI findings.
► Direct visualization of subthalamic nucleus with P904.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 58, Issue 1, 1 September 2011, Pages 60–68
نویسندگان
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