کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3073010 | 1188820 | 2008 | 7 صفحه PDF | دانلود رایگان |

BackgroundDetails of the internal hippocampal structure visible at 4 T allow for in vivo volumetry of subfields. The aims of this study were: 1. To determine if Apo e4 has subfield specific effects in controls. 2. To study the influence of Apo e4 on hippocampal subfields in AD.Methods81 subjects (66 controls, mean age 60.8 ± 13.6, range: 28–85 years), and 15 AD (mean age 67.5 ± 9.3) were studied. Entorhinal cortex, subiculum, CA1, CA1–CA2 transition zone, CA3–4 and dentate gyrus (CA3&DG) and total hippocampal volume were determined using a manual marking strategy.ResultsSignificant effects for Apo e4 on the CA3&DG were found in the total control population (p = 0.042) and in older controls (61–85 years) (p = 0.036) but not in younger (28–60 years) controls. Significant effects for Apo e4 (p = 0.0035) on CA3&DG were also found in a subgroup of older subjects and AD subjects. AD with Apo e4 had smaller CA3&DG than AD without Apo e4 (p = 0.027).ConclusionsThese findings suggest that Apo e4 exerts a regionally selective effect on CA3&DG in normal aging and AD.
Journal: NeuroImage - Volume 42, Issue 1, 1 August 2008, Pages 42–48