کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3073010 1188820 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T
چکیده انگلیسی

BackgroundDetails of the internal hippocampal structure visible at 4 T allow for in vivo volumetry of subfields. The aims of this study were: 1. To determine if Apo e4 has subfield specific effects in controls. 2. To study the influence of Apo e4 on hippocampal subfields in AD.Methods81 subjects (66 controls, mean age 60.8 ± 13.6, range: 28–85 years), and 15 AD (mean age 67.5 ± 9.3) were studied. Entorhinal cortex, subiculum, CA1, CA1–CA2 transition zone, CA3–4 and dentate gyrus (CA3&DG) and total hippocampal volume were determined using a manual marking strategy.ResultsSignificant effects for Apo e4 on the CA3&DG were found in the total control population (p = 0.042) and in older controls (61–85 years) (p = 0.036) but not in younger (28–60 years) controls. Significant effects for Apo e4 (p = 0.0035) on CA3&DG were also found in a subgroup of older subjects and AD subjects. AD with Apo e4 had smaller CA3&DG than AD without Apo e4 (p = 0.027).ConclusionsThese findings suggest that Apo e4 exerts a regionally selective effect on CA3&DG in normal aging and AD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 42, Issue 1, 1 August 2008, Pages 42–48
نویسندگان
, , , , ,