کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3073496 1188839 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Visualization of the deep cerebellar nuclei using quantitative T1 and ρ magnetic resonance imaging at 3 Tesla
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Visualization of the deep cerebellar nuclei using quantitative T1 and ρ magnetic resonance imaging at 3 Tesla
چکیده انگلیسی

The cerebellum coordinates movement, thought and emotion through its feedback projections from the deep cerebellar nuclei. Despite recent advancement in our understanding of the functions of the cerebellar cortex, little is known about the functional correlates of the deep cerebellar nuclei in humans. This is mainly due to the inability of current MRI techniques to visualize the cerebellar nuclei and therefore perform in vivo clinico-anatomical correlation studies in patient populations. Here we visualize in vivo the detailed anatomy of the dentate nucleus and other cerebellar nuclei using quantitative T1 and proton density (ρ) imaging. Compared to conventional qualitative T1, T2 or T2⁎-weighted imaging, quantitative T1 and proton density (ρ) imaging facilitates direct visualization of the dentate and interposed nuclei, allowing us to perform segmentation and volumetric measurements of the dentate nucleus. Also the fine architecture of the microgyric and macrogyric dentate nucleus was visible on the high-resolution images. The high concentration of paramagnetic iron within the cerebellar nuclei and the resulting local field inhomogeneities surrounding the iron-containing nuclei is believed to be responsible for the observed effect on T1 and proton density signal. The application of this technique to disorders with cerebellar dysfunction could provide new insight into pathologies like autism and movement disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 37, Issue 4, 1 October 2007, Pages 1260–1266
نویسندگان
, ,