کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3073725 | 1188850 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Direct MRI detection of neuronal magnetic fields in the brain: Theoretical modeling
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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چکیده انگلیسی
Whether MRI can be used for direct detection of neuronal activity is a matter of debate. Controversial theoretical and experimental results have been reported. Here, we present an improved current-dipole model to compute magnetic field generated by neural firing and to calculate MRI signal changes resulting from the neuronal magnetic field (NMF). Each dendrite or each unmyelinated axon was modeled as a modified current-dipole. NMF were estimated based on a synchronized activity of multiple neurons. Sensitivity of using phase and magnitude MRI to measure effects of NMF was evaluated. Our results show that NMF can potentially generate up to a few percent changes in MRI magnitude signals. Phases of MRI signal tend to be destructively added and are insensitive to NMF in the activated region when the distribution of the activated dendrites is symmetrical. Phases could be detected when the distribution of the activated dendrites is asymmetrical and on some neighboring voxels. Our modeling implies that direct MRI detection of neuronal activity is possible.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 31, Issue 2, June 2006, Pages 550-559
Journal: NeuroImage - Volume 31, Issue 2, June 2006, Pages 550-559
نویسندگان
Yiqun Xue, Jia-Hong Gao, Jinhu Xiong,