کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3074988 1580959 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease
ترجمه فارسی عنوان
اتصال به عملکرد نامطلوب در گانگلیس پایه بیماران مبتلا به پارکینسون
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• We assess resting state connectivity within the basal ganglia network of patients with PD, AD and healthy controls.
• Connectivity within the basal ganglia is significantly lower in patients with PD, compared to the other two groups.
• Changes are likely to represent basal ganglia dysfunction and are not associated with generalised neurodegeneration.
• We differentiated patients with PD from those with AD and healthy control subjects with a diagnostic accuracy of 81%.

Resting state functional MRI (rs-fMRI) has been previously shown to be a promising tool for the assessment of early Parkinson's disease (PD). In order to assess whether changes within the basal ganglia network (BGN) are disease specific or relate to neurodegeneration generally, BGN connectivity was assessed in 32 patients with early PD, 19 healthy controls and 31 patients with Alzheimer's disease (AD). Voxel-wise comparisons demonstrated decreased connectivity within the basal ganglia of patients with PD, when compared to patients with AD and healthy controls. No significant changes within the BGN were seen in AD, when compared to healthy controls. Moreover, measures of functional connectivity extracted from regions within the basal ganglia were significantly lower in the PD group. Consistent with previous radiotracer studies, the greatest change when compared to the healthy control group was seen in the posterior putamen of PD subjects. When combined into a single component score, this method differentiated PD from AD and healthy control subjects, with a diagnostic accuracy of 81%. Rs-fMRI can be used to demonstrate the aberrant functional connectivity within the basal ganglia of patients with early PD. These changes are likely to be representative of patho-physiological basal ganglia dysfunction and are not associated with generalised neurodegeneration seen in AD. Further studies are necessary to ascertain whether this method is sensitive enough to detect basal ganglia dysfunction in prodromal PD, and its utility as a potential diagnostic biomarker for premotor and early motoric disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 8, 2015, Pages 126–132
نویسندگان
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