کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3074999 1580959 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hippocampal volume correlates with attenuated negative psychotic symptoms irrespective of antidepressant medication
ترجمه فارسی عنوان
حجم هیپوکامپ با علائم روان پریشی منفی ضعیف ارتباط دارد بدون توجه به داروهای ضد افسردگی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• We compared brain structure in high-risk patients with/without antidepressants (AD).
• We found attenuated negative psychotic symptoms (ANS) irrespective of AD.
• We found a significant correlation between ANS and hippocampal volume.
• Results indicate relevance of ANS for clinical high-risk studies.

BackgroundIndividuals with at-risk mental state for psychosis (ARMS) often suffer from depressive and anxiety symptoms, which are clinically similar to the negative symptomatology described for psychosis. Thus, many ARMS individuals are already being treated with antidepressant medication.ObjectivesTo investigate clinical and structural differences between psychosis high-risk individuals with or without antidepressants.MethodsWe compared ARMS individuals currently receiving antidepressants (ARMS-AD; n = 18), ARMS individuals not receiving antidepressants (ARMS-nonAD; n = 31) and healthy subjects (HC; n = 24), in terms of brain structure abnormalities, using voxel-based morphometry. We also performed region of interest analysis for the hippocampus, anterior cingulate cortex, amygdala and precuneus.ResultsThe ARMS-AD had higher ‘depression’ and lower ‘motor hyperactivity’ scores than the ARMS-nonAD. Compared to HC, there was significantly less GMV in the middle frontal gyrus in the whole ARMS cohort and in the superior frontal gyrus in the ARMS-AD subgroup. Compared to ARMS-nonAD, the ARMS-AD group showed more gray matter volume (GMV) in the left superior parietal lobe, but less GMV in the left hippocampus and the right precuneus. We found a significant negative correlation between attenuated negative symptoms and hippocampal volume in the whole ARMS cohort.ConclusionReduced GMV in the hippocampus and precuneus is associated with short-term antidepressant medication and more severe depressive symptoms. Hippocampal volume is further negatively correlated with attenuated negative psychotic symptoms. Longitudinal studies are needed to distinguish whether hippocampal volume deficits in the ARMS are related to attenuated negative psychotic symptoms or to antidepressant action.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 8, 2015, Pages 230–237
نویسندگان
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