کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3075042 1580959 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A multi-contrast MRI study of microstructural brain damage in patients with mild cognitive impairment
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
A multi-contrast MRI study of microstructural brain damage in patients with mild cognitive impairment
چکیده انگلیسی


• Forty-two MCI patients and 77 HC underwent multi-contrast quantitative MRI.
• MCI patients showed T1/T2* increase and MTR decrease in the hippocampus.
• MCI patients exhibited T1 increase in WM and T2* decrease in the pallidus.
• MRI metrics accurately predicted memory and executive function in patients.
• SVM classified MCI patients with 75% accuracy using volumetric/parametric MRI.

ObjectivesThe aim of this study was to investigate pathological mechanisms underlying brain tissue alterations in mild cognitive impairment (MCI) using multi-contrast 3 T magnetic resonance imaging (MRI).MethodsForty-two MCI patients and 77 healthy controls (HC) underwent T1/T2* relaxometry as well as Magnetization Transfer (MT) MRI. Between-groups comparisons in MRI metrics were performed using permutation-based tests. Using MRI data, a generalized linear model (GLM) was computed to predict clinical performance and a support-vector machine (SVM) classification was used to classify MCI and HC subjects.ResultsMulti-parametric MRI data showed microstructural brain alterations in MCI patients vs HC that might be interpreted as: (i) a broad loss of myelin/cellular proteins and tissue microstructure in the hippocampus (p ≤ 0.01) and global white matter (p < 0.05); and (ii) iron accumulation in the pallidus nucleus (p ≤ 0.05). MRI metrics accurately predicted memory and executive performances in patients (p ≤ 0.005). SVM classification reached an accuracy of 75% to separate MCI and HC, and performed best using both volumes and T1/T2*/MT metrics.ConclusionMulti-contrast MRI appears to be a promising approach to infer pathophysiological mechanisms leading to brain tissue alterations in MCI. Likewise, parametric MRI data provide powerful correlates of cognitive deficits and improve automatic disease classification based on morphometric features.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 8, 2015, Pages 631–639
نویسندگان
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