کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3075072 1580960 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Early neural activation during facial affect processing in adolescents with Autism Spectrum Disorder
ترجمه فارسی عنوان
فعال سازی عصبی اولیه در طی پردازش عوارض صورت در نوجوانان مبتلا به اختلال اسپکتروم اوتیسم
کلمات کلیدی
پردازش چهره نامنظم، نوجوانان، اختلال اسپکتروم اوتیسم، مغناطیس فوگلوگرافی، تأثیر پردازش، قشر مفاصل قدامی قدامی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• The ability to recognize and interpret emotions is central to social interaction.
• Deficits in social interactions are hallmarks of autism spectrum disorder (ASD).
• Adolescents with and without ASD completed an emotional face task in MEG.
• MEG data showed atypical neural activity in ASD to both angry and happy faces.
• Insula, cingulate, temporal and orbitofrontal activities were particularly affected in the ASD group.

Impaired social interaction is one of the hallmarks of Autism Spectrum Disorder (ASD). Emotional faces are arguably the most critical visual social stimuli and the ability to perceive, recognize, and interpret emotions is central to social interaction and communication, and subsequently healthy social development. However, our understanding of the neural and cognitive mechanisms underlying emotional face processing in adolescents with ASD is limited. We recruited 48 adolescents, 24 with high functioning ASD and 24 typically developing controls. Participants completed an implicit emotional face processing task in the MEG. We examined spatiotemporal differences in neural activation between the groups during implicit angry and happy face processing. While there were no differences in response latencies between groups across emotions, adolescents with ASD had lower accuracy on the implicit emotional face processing task when the trials included angry faces. MEG data showed atypical neural activity in adolescents with ASD during angry and happy face processing, which included atypical activity in the insula, anterior and posterior cingulate and temporal and orbitofrontal regions. Our findings demonstrate differences in neural activity during happy and angry face processing between adolescents with and without ASD. These differences in activation in social cognitive regions may index the difficulties in face processing and in comprehension of social reward and punishment in the ASD group. Thus, our results suggest that atypical neural activation contributes to impaired affect processing, and thus social cognition, in adolescents with ASD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 7, 2015, Pages 203–212
نویسندگان
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