کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3075193 1580958 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adaptive grip force is modulated by subthalamic beta activity in Parkinson's disease patients
ترجمه فارسی عنوان
نیروی گیرنده انعطاف پذیر توسط فعالیت بتای زیراتالامام در بیماران مبتلا به بیماری پارکینسون مدولاسیون می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Subthalamic nucleus is involved in anticipatory grip force control in PD patients.
• Subthalamic beta activity is the first derivative of grip force in a shaking task.
• Synchronization between STN and cortex is reduced during the shaking task.

IntroductionHealthy subjects scale grip force to match the load defined by physical object properties such as weight, or dynamic properties such as inertia. Patients with Parkinson's disease (PD) show an elevated grip force in dynamic object handling, but temporal aspects of anticipatory grip force control are relatively preserved. In PD patients, beta frequency oscillatory activity in the basal ganglia is suppressed prior to externally paced movements. However, the role of the subthalamic nucleus (STN) in anticipatory grip force control is not known.MethodsAfter implantation of deep brain stimulation (DBS) electrodes in the STN, PD patients performed adaptive and voluntary grip force tasks, while we recorded subthalamic local field potentials (LFP) and scalp EEG.ResultsDuring adaptive grip force control (Shake), we found event related desynchronization (ERD) in the beta frequency band, which was time-locked to the grip force. In contrast, during voluntary grip force control (Press) we recorded a biphasic ERD, corresponding to peak grip force and grip force release. Beta synchronization between STN and cortical EEG was reduced during adaptive grip force control.ConclusionThe time-locked suppression of beta oscillatory activity in the STN is in line with previous reports of beta ERD prior to voluntary movements. Our results show that the STN is involved in anticipatory grip force control in PD patients. The difference in the phasic beta ERD between the two tasks and the reduction of cortico-subthalamic synchronization suggests that qualitatively different neuronal network states are involved in different grip force control tasks.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 9, 2015, Pages 450–457
نویسندگان
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