کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3075338 1580963 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
fMRI resting state networks and their association with cognitive fluctuations in dementia with Lewy bodies
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
fMRI resting state networks and their association with cognitive fluctuations in dementia with Lewy bodies
چکیده انگلیسی


• We report resting state network (RSN) alterations in dementia with Lewy bodies (DLB).
• The default mode network was intact in DLB compared to healthy controls (HC).
• Fronto-parietal, temporal, and sensory–motor RSNs showed differences (DLB < HC).
• The left fronto-parietal network (FPN) correlated with cognitive fluctuations in DLB.
• The FPN therefore may be a potential marker for cognitive fluctuations in DLB.

Cognitive fluctuations are a core symptom in dementia with Lewy bodies (DLB) and may relate to pathological alterations in distributed brain networks. To test this we analysed resting state fMRI changes in a cohort of fluctuating DLB patients (n = 16) compared with age matched controls (n = 17) with the aim of finding functional connectivity (FC) differences between these two groups and whether these associate with cognitive fluctuations in DLB. Resting state networks (RSNs) were estimated using independent component analysis and FC between the RSN maps and the entirety of the brain was assessed using dual regression. The default mode network (DMN) appeared unaffected in DLB compared to controls but significant cluster differences between DLB and controls were found for the left fronto-parietal, temporal, and sensory–motor networks. Desynchronization of a number of cortical and subcortical areas related to the left fronto-parietal network was associated with the severity and frequency of cognitive fluctuations. Our findings provide empirical evidence for the potential role of attention–executive networks in the aetiology of this core symptom in DLB.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 4, 2014, Pages 558–565
نویسندگان
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