کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3079274 | 1189293 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assessment of a symptomatic Duchenne muscular dystrophy carrier 20Â years after myoblast transplantation from her asymptomatic identical twin sister
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Because it is due to a mutation on the X-chromosome, Duchenne muscular dystrophy rarely affects women, unless there is an unequal lyonisation of the X-chromosome containing the normal dystrophin gene. We report here the unique situation of a symptomatic Duchenne muscular dystrophy woman who was transplanted with myoblasts received from her asymptomatic monozygotic twin sister 20Â years ago. Specific dynamometry was performed to possibly detect a long-term effect of this cell therapy. Long-term safety of myoblast transplantation was established by this exceptional case. However, long-term efficacy could not be definitively asserted for this patient, in spite of several clues suggesting beneficial effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 23, Issue 7, July 2013, Pages 575-579
Journal: Neuromuscular Disorders - Volume 23, Issue 7, July 2013, Pages 575-579
نویسندگان
Jean-Yves Hogrel, Fabien Zagnoli, Aurélie Canal, Bodvael Fraysse, Jean-Pierre Bouchard, Daniel Skuk, Michel Fardeau, Jacques P. Tremblay,