کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3081568 | 1189380 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Corticosteroid treatment retards development of ventricular dysfunction in Duchenne muscular dystrophy
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کلمات کلیدی
SBPVelocity of circumferential fiber shorteningVCFcleft ventricular end diastolic dimensionMWSLVEDdLVMIDMDDBPHeight - ارتفاعechocardiography - اکوکاردیوگرافیDeflazacort - دفلاکارکردDuchenne muscular dystrophy - دیستروفی عضلانی دوشنMuscular dystrophy - دیستروفی ماهیچهای، دیستروفی عضلانیHeart rate - ضربان قلبdiastolic blood pressure - فشار خون دیاستولیکsystolic blood pressure - فشار خون سیستولیکWeight - وزنPrednisone - پیشینسونShortening fraction - کسری کوتاه
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Duchenne muscular dystrophy (DMD) is characterized by a predictable decline in cardiac function with age that contributes to early death. Although corticosteroids are a clinically effective pharmacologic therapy for skeletal muscle function, there is limited published work documenting the impact on cardiac function. The primary objective of this work is to determine benefit from steroid treatment on the development of ventricular dysfunction in DMD. We performed a historical cohort study of DMD cases undergoing serial cardiac evaluations from 1998-2006. In addition to the history of steroid use, basic medical characteristics and serial echocardiographic measures were obtained for each identified case meeting inclusion criteria. Data from initial (7.5 ± 0.8 years) and follow-up (12 ± 0.7 years) evaluation was collected from untreated (n = 23) and steroid treated (n = 14) DMD cases. Kaplan-Meier freedom from ventricular dysfunction was 93% for steroid treated cases versus 53% for untreated cases at 1500 days. Treatment with steroids was protective against ventricular dysfunction (Hazard ratio 0.16 95% CI 0.04, 0.70). We demonstrate here that steroid treatment, begun prior to ventricular dysfunction retards the anticipated development of ventricular dysfunction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 18, Issue 5, May 2008, Pages 365-370
Journal: Neuromuscular Disorders - Volume 18, Issue 5, May 2008, Pages 365-370
نویسندگان
Larry W. Markham, Kathi Kinnett, Brenda L. Wong, D. Woodrow Benson, Linda H. Cripe,