A New Sesquiterpenoid Glycoside from Rhizomes of Atractylodes lancea

ObjectiveTo study the water-soluble chemical constituents from the rhizomes of Atratylodes lancea.MethodsTwo sesquiterpenoid glycosides were purified by column chromatography and their structures were determined by spectroscopic analysis. They were also evaluated for anti-inflammatory activity by determining the inhibitory activity on LPS-induced NO and PGE2 generation in RAW 264.7 cell lines.ResultsCompound 1 was a new sesquiterpenoid glycoside, named as (1S,4S,5R,7R,10S)-4,11,14-trihydroxy-guai-3-one-11-O-β-D-glucopyranoside, but exhibited no appreciable activity. Compound 2 was atractyloside A and showed weak activity.ConclusionThe hydroxyl group at C-10 of guaiol-type glycoside could be important for anti-inflammatory activity.