Triterpene Glycosides from Sea Cucumber Holothuria scabra with Cytotoxic Activity

ObjectiveTo study the new triterpene glycosides from sea cucumber Holothuria scabra with cytotoxic activity.MethodsTriterpene glycosides from H. scabra were separated and purified by chromatography on DA-101, silica gel, and reversed-phase silica gel column, as well as RP-HPLC. Their structures were elucidated on the basis of spectral data and chemical evidence.ResultsThree triterpene glycosides were identified as scabraside D (1), fuscocineroside C (2), and 24-dehydroechinoside A (3). Their inhibition on P-388, A549, MKN-28, HCT116, and MCF-7 cells were significant.ConclusionScabraside D (1) is a new triterpene glycoside, and compounds 2 and 3 are isolated from H. scabra for the first time. The glycosides 1–3 show the in vitro cytotoxicity against five human tumor cell lines in comparison to 10-hydroxycamptothecin.