Antihyperglycemic Effect of Various Fractions from Residues of Blumea balsamifera

ObjectiveTo evaluate the antihyperglycemic activities of various fractions from the residues of Blumea balsamifera (BB), and to properly utilize the waste resource.MethodsThe antihyperglycemic activities were evaluated by the suppression on serum glucose level in vivo and α-glucosidase inhibition assay in vitro. The high-, mid-, and low-dose (1, 0.5, and 0.25 g/kg of the herb) fractions were ig given to mice for 8 d. The serum glucose was monitored at 1 and 12 h after feeding.ResultsThe fasting and postprandial serum glucose levels of mice treated with high-dose petroleum ether fraction, ethyl acetate fraction, butyl alcohol fraction, methanol fraction, and water extract from BB were 4.45, 4.39, 4.43, 4.15, 3.74 mmol/L and 6.98, 6.23, 6.45, 6.26, 5.88 mmol/L, respectively, while those in vehicle control group were 5.63 and 7.50 mmol/L. There are four different inhibiting manners by the results of α-glucosidase inhibition assay.ConclusionThe residues of BB have anti-diabetes activities after steam distillation.