Meta-analysis on protective effect of electroacupuncture at “Nèiguān” ( PC 6) in rats with reperfusion injury induced myocardial ischemia

ObjectiveTo systematically evaluate the protection effect of electroacupuncture at “Nèiguān” ( PC 6) on myocardial damage by means of evidence-based medicine.MethodsDatabases were retrieved by computer, while dissertation compilations and conference proceedings were searched manually. Data were analyzed statistically by using RevMan5.2 software.ResultsTwelve studies were enrolled. Compared with myocardial ischemia reperfusion injury model group, the magnitude of ECG ST II segment elevation can be reduced by means of electroacupuncture at PC 6 (WMD= –73.95, 95%CI[–109.69, –38.20]) and the difference was statistically significant (P<0.0001); the ATPase in myocardial cells can be increased by means of electroacupuncture at PC 6 (SMD=2.28, 95% CI [1.50, 3.07]) and the difference was statistically significant (P<0.00001); the release of cTnT can be reduced by means of electroacupuncture at PC 6 (WMD= –2.69, 95%CI[–3.16, –2.22]) and the difference was statistically significant (P<0.00001); the size of myocardial infarction can be reduced by means of electroacupuncture at PC 6 (WMD= –17.99, 95% CI [–19.88, –16.09]) and the difference was statistically significant (P<0.00001); the release of CK can be reduced by means of electroacupuncture at PC 6 (WMD= –0.44, 95%CI[–0.61, –0.27]) and the difference was statistically significant (P<0.00001); the release of CK-MB can be reduced by means of electroacupuncture at PC 6 (SMD=–2.85, 95%CI[–4.46, –1.24]) and the difference was statistically significant (P<0.001); the release of LDH can be reduced by means of electroacupuncture at PC 6 (SMD=–2.97, 95%CI [–4.87, –1.07]) and the difference was statistically significant (P<0.01).ConclusionBased on the current experimental evidences, electroacupuncture at PC 6 has a higher protective effect on myocardium.