کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3104297 1191648 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Feasibility study of an active wound dressing based on hollow fiber membranes in a porcine wound model
ترجمه فارسی عنوان
مطالعه امکان سنجی پوشش پانسمان فعال زخم بر اساس غشاهای فیبر توخالی در یک مدل زخم گوشت خوک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
چکیده انگلیسی

InvestigationA novel active wound dressing (AWD) concept based on a microporous hollow fiber membrane network was investigated in an animal model. It provides a local solution-perfused environment for regenerative cell nutrition, wound irrigation, debris removal, electrolyte balancing, pH regulation, and topical antibiosis. The device is capable of supplying soluble factors, as tested experimentally for the recombinant human growth and differentiation factor-5 (rhGDF-5).MethodsFollowing in vitro studies for rhGDF-5 using primary human keratinocytes and dermal fibroblasts, we employed a porcine partial thickness wound model with five distinct wounds on each back of n = 8 pigs. Four wound groups were perfused differently over 9 days and compared with a negative control wound without perfusion: (1) 1% trehalose solution, pH 5.5; (2) rhGDF-5 (150 ng/ml) in 1% trehalose solution, pH 5.5; (3) nutrition solution; and (4) rhGDF-5 (150 ng/ml) in nutrition solution with 1% trehalose, pH 5.5.ResultsPromoted wound healing was observed within group 1 and more pronounced within group 2. Groups 3 and 4, with nutrition solution, showed significant adverse effects on wound healing (p < 0.05).ConclusionsThe investigated AWD concept appears to be an interesting therapeutic tool to study further wound healing support. Additionally, topical application of rhGDF-5 could be promising.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 41, Issue 4, June 2015, Pages 778–788
نویسندگان
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