کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3104835 1191665 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oral ketamine and dexmedetomidine in adults’ burns wound dressing—A randomized double blind cross over study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Oral ketamine and dexmedetomidine in adults’ burns wound dressing—A randomized double blind cross over study
چکیده انگلیسی

Study was designed to compare analgesic efficacy and side effects of oral dexmedetomidine and ketamine in adults for burn wound dressing.Sixty healthy adults with thermal burns with burn area (20–50%) were randomly assigned into 2 groups. In Group K 5 mg/kg ketamine and in Group D 4 mcg/kg dexmedetomidine was given orally. Patients crossed over to the other group the following day. Visual analogue score, sedation score, haemodynamic parameters were recorded from 30 min after drug administration to 2 h after procedure. Patients’ preference was also recorded.Mean VAS score was significantly reduced from baseline in both the groups at all time points (P < 0.05). Pain relief in Group K (overall mean VAS 2.6 ± 0.6 cm) was significantly better when compared to Group D (overall mean VAS 3.8 ± 0.8 cm). Patients in group K were significantly more sedated (median 3) when compared to group D (median 2), P < 0.05. Delirium and excessive salivation were significant complications observed with ketamine. More patients preferred ketamine (63.3%) than dexmedetomidine (36.7%), P < 0.05.Oral ketamine and dexmedetomidine produced significant pain relief during burns wound dressing. Oral ketamine produced significantly better pain relief than dexmedetomidine but was associated with delirium and excessive salivation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 39, Issue 6, September 2013, Pages 1150–1156
نویسندگان
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