کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3104835 | 1191665 | 2013 | 7 صفحه PDF | دانلود رایگان |

Study was designed to compare analgesic efficacy and side effects of oral dexmedetomidine and ketamine in adults for burn wound dressing.Sixty healthy adults with thermal burns with burn area (20–50%) were randomly assigned into 2 groups. In Group K 5 mg/kg ketamine and in Group D 4 mcg/kg dexmedetomidine was given orally. Patients crossed over to the other group the following day. Visual analogue score, sedation score, haemodynamic parameters were recorded from 30 min after drug administration to 2 h after procedure. Patients’ preference was also recorded.Mean VAS score was significantly reduced from baseline in both the groups at all time points (P < 0.05). Pain relief in Group K (overall mean VAS 2.6 ± 0.6 cm) was significantly better when compared to Group D (overall mean VAS 3.8 ± 0.8 cm). Patients in group K were significantly more sedated (median 3) when compared to group D (median 2), P < 0.05. Delirium and excessive salivation were significant complications observed with ketamine. More patients preferred ketamine (63.3%) than dexmedetomidine (36.7%), P < 0.05.Oral ketamine and dexmedetomidine produced significant pain relief during burns wound dressing. Oral ketamine produced significantly better pain relief than dexmedetomidine but was associated with delirium and excessive salivation.
Journal: Burns - Volume 39, Issue 6, September 2013, Pages 1150–1156