کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3105053 1191671 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vagus nerve stimulation blocks vascular permeability following burn in both local and distal sites
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Vagus nerve stimulation blocks vascular permeability following burn in both local and distal sites
چکیده انگلیسی

Recent studies have shown that vagus nerve stimulation (VNS) can block the burn-induced systemic inflammatory response (SIRS). In this study we examined the potential for VNS to modulate vascular permeability (VP) in local sites (i.e. skin) and in secondary sites (i.e. lung) following burn. In a 30% total body surface area burn model, VP was measured using intravascular fluorescent dextran for quantification of the VP response in skin and lung. A peak in VP of the skin was observed 24 h post-burn injury, that was blocked by VNS. Moreover, in the lung, VNS led to a reduction in burn-induced VP compared to sham-treated animals subjected to burn alone. The protective effects of VNS in this model were independent of the spleen, suggesting that the spleen was not a direct mediator of VNS. These studies identify a role for VNS in the regulation of VP in burns, with the translational potential of attenuating lung complications following burn.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 39, Issue 1, February 2013, Pages 68–75
نویسندگان
, , , , ,