کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3105755 1191693 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A randomised controlled trial of amniotic membrane in the treatment of a standardised burn injury in the merino lamb
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
A randomised controlled trial of amniotic membrane in the treatment of a standardised burn injury in the merino lamb
چکیده انگلیسی

Burn injury is associated with disabling scar formation which impacts on many aspects of the patient's life. Previously we have shown that the fetus heals a deep dermal burn in a scarless fashion. Amniotic membrane (AM) is the outermost fetal tisue and has beeen used as a dressing in thermal injuries, though there is little data to support this use. To assess the efficacy of AM in scar minimisation after deep dermal burn wound, we conducted a randomised controlled study in the 1-month lamb. Lambs were delivered by caesarian section and the amniotic membranes stored after which lambs were returned to their mothers post-operatively. At 1 month, a standardised deep dermal burn was created under general anaesthesia on both flanks of the lamb. One flank was covered with unmatched AM, the other with paraffin gauze. Animals were sequentially euthanased from Day 3–60 after injury and tissue analysed for histopathology and immunohistochemically for α-smooth muscle actin (αSMA) content. AM resulted in reduced scar tissue as assessed histopathologically and reduced αSMA content. This study provides the first laboratory evidence that AM may reduce scar formation after burn injury.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 35, Issue 7, November 2009, Pages 998–1003
نویسندگان
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