کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3106221 1191703 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Decreased production of MCP-1 and MMP-2 by keloid-derived fibroblasts
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Decreased production of MCP-1 and MMP-2 by keloid-derived fibroblasts
چکیده انگلیسی

Keloid tissue results from aberrant wound healing. The underlying mechanism responsible for keloid formation remains unclear. The aim of this study was to analyse the production of tissue inflammatory mediators by normal and keloid-derived human dermal fibroblasts cultured in vitro. Production of monocyte chemoattractant protein 1 (MCP-1), matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2), with and without the addition of interleukin-1β, was determined by enzyme-linked immunosorbant assay. Our results showed that IL-1β (10 ng/ml) stimulated a statistically significant increase in MCP-1 and MMP-2 production and decreased production of TIMP-2 by both normal and keloid-derived fibroblasts (Student’s t-test, p < 0.05), but to differing extents. This may contribute to factors leading to keloid formation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 35, Issue 3, May 2009, Pages 348–351
نویسندگان
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