کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3106398 1191710 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Temporal expression of activin in acute burn wounds—From inflammatory cells to fibroblasts
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Temporal expression of activin in acute burn wounds—From inflammatory cells to fibroblasts
چکیده انگلیسی

Activin A is a member of the transforming growth factor-β (TGF-β) family of cytokines and growth factors and upregulation of this protein has been linked with a number of disease processes associated with chronic inflammation and fibrosis. Its potential involvement in burns has not yet been investigated. We therefore studied the localization of activin in tissue sections from excised mid- and deep dermal and full thickness cutaneous burn by immunohistochemistry. There was cell-specific temporal expression in tissues with prominent expression from day 4 onwards in lymphocytes and histiocytes and expression from day 8 onwards in reactive fibroblasts and endothelial cells. Immunopositivity over the first 18 days persisted in reactive fibroblasts and lymphocytes although the latter were in most circumstances decreasing in number. These data are consistent with activin A being central to the inflammatory and repair phases occurring in burnt skin and early scar formation. Modulation of activin expression and actions may, therefore, be a target for the management of burns.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 34, Issue 1, February 2008, Pages 50–55
نویسندگان
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