کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3106440 1191712 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The mobilisation of mononuclear cells and endothelial progenitor cells after burn injury in a porcine model
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
The mobilisation of mononuclear cells and endothelial progenitor cells after burn injury in a porcine model
چکیده انگلیسی

BackgroundMononuclear blood cells (MNCs) consist of heterogeneous cell populations, for example, CD34+ cells and endothelial progenitor cells (EPCs). EPCs are involved in vasculogenesis, but little is known about their role during burn trauma.AimThis study investigates the role of MNCs and their subpopulations during and after burn injury in an experimental porcine setting.MethodsEighteen 8-week-old German land pigs were scalded by immersion in 70 °C hot water for 3 min, resulting in a 30% total body surface area (TBSA) full-thickness burn. Vascular endothelial growth factor (VEGF) serum concentrations and MNC, EPC and CD34+ cell counts were measured at eight different time points up to 48 h following trauma.ResultsThe experimental porcine setting made it possible to determine the cell counts of MNCs, EPCs and CD34+ cells directly during burn trauma, which has not been described before. The data revealed a fulminant drop in MNC and EPC during burn trauma, whereas the CD34+ cell fraction rose. Besides significant changes in the VEGF serum concentration, a correlation between VEGF and EPC was also observed.ConclusionThe results show that MNCs and their subpopulations are significantly affected by burn trauma and underpin their potential diagnostic and therapeutic importance during and after burn injury.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 36, Issue 4, June 2010, Pages 545–551
نویسندگان
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