کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3106650 | 1191728 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Changes of endothelin-1 expression in cerebral basilar arteries of scald rats
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Changes of endothelin-1 expression in cerebral basilar arteries of scald rats Changes of endothelin-1 expression in cerebral basilar arteries of scald rats](/preview/png/3106650.png)
چکیده انگلیسی
The purpose of this study was to investigate the influences of scald on endothelin-1 (ET-1) expression in cerebral vessels of rats, and to further elucidate the relationship between changes of ET-1 expression and scald-induced cerebral vascular remodelling resulting in cerebral vasospasm. The ET-1 levels in the cerebral basilar arteries were estimated by radioimmunoassay. Expression of ET-1 and its mRNA were determined by Western blotting and reverse transcriptase polymerase chain reaction (RT-PCR), respectively. Changes of cerebral basilar artery histology were observed and diameters were measured by angiography. The results showed that the ET-1 levels at 3Â h after scald were enhanced, peaking at 12Â h; the expression of ET-1 mRNA was also enhanced, peaking at 6Â h. Simultaneous vascular remodelling was observed in the cerebral basilar arteries, vasoconstriction peaking at 12Â h. It is suggested that ET-1 plays an important role in the pathogenesis of scald-induced cerebral vasospasm and cerebral circulation disorder.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 35, Issue 1, February 2009, Pages 98-103
Journal: Burns - Volume 35, Issue 1, February 2009, Pages 98-103
نویسندگان
Xuequn Lin, Yucheng Dai, Gaochun Zhu, Lidan Wan,