کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3116844 1582724 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association analysis of clinical aspects and vitamin D receptor gene polymorphism with external apical root resorption in orthodontic patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Association analysis of clinical aspects and vitamin D receptor gene polymorphism with external apical root resorption in orthodontic patients
چکیده انگلیسی

IntroductionVitamin D is responsible for the regulation of certain genes at the transcription level, via interaction with the vitamin D receptor, and influences host immune responses and aspects of bone development, growth, and homeostasis. Our aim was to investigate the association of TaqI vitamin D receptor gene polymorphism with external apical root resorption during orthodontic treatment.MethodsOur subjects were 377 patients with Class II Division 1 malocclusion, divided into 3 groups: (1) 160 with external apical root resorption ≤1.43 mm, (2) 179 with external apical root resorption >1.43 mm), and (3) 38 untreated subjects. External apical root resorption of the maxillary incisors was evaluated on periapical radiographs taken before and after 6 months of treatment. After DNA collection and purification, vitamin D receptor TaqI polymorphism analysis was performed by polymerase chain reaction-restriction fragment length polymorphism. Univariate and multivariate analyses were performed to verify the association of clinical and genetic variables with external apical root resorption (P <0.05).ResultsThere was a higher proportion of external apical root resorption in orthodontically treated patients compared with the untreated subjects. In patients orthodontically treated, age higher than 14 years old, initial size of the maxillary incisor root superior to 30 mm, and premolar extraction were associated with increased external apical root resorption. Genotypes containing the C allele were weakly associated with protection against external apical root resorption (CC + CT × TT [odds ratio, 0.29; 95% confidence interval, 0.07-1.23; P = 0.091]) when treated orthodontic patients were compared to untreated individuals.ConclusionsClinical factors and vitamin D receptor TaqI polymorphism were associated with external apical root resorption in orthodontic patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Orthodontics and Dentofacial Orthopedics - Volume 142, Issue 3, September 2012, Pages 339–347
نویسندگان
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