کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3117043 | 1582711 | 2013 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice](/preview/png/3117043.png)
IntroductionIn this study, mechanical stress in the form of tooth movement was applied to osteoprotegerin-deficient knockout mice, which served as an animal model for juvenile Paget’s disease. To compare and evaluate bone turnover and response of the surrounding bony tissue, we administered reveromycin A. We also investigated the ability of reveromycin A to control osteoclastic activity in juvenile Paget’s disease.MethodsEight-week-old male osteoprotegerin-deficient knockout and wild-type mice were injected with reveromycin A (15 mg/kg of body weight) intraperitoneally twice daily. An elastic module was inserted interproximally between the maxillary left first and second molars.ResultsAdministration of reveromycin A to osteoprotegerin-deficient knockout mice reduced tooth movement distances, increased bone volumes at the interradicular septum, decreased osteoclast counts, and reduced serum alkaline phosphatase and tartrate resistant acid phosphatase. Reveromycin A administration also caused a temporal shift in peak Runx2 staining in osteoprotegerin-deficient knockout mice so that the overall staining time course was similar to that observed for wild-type mice.ConclusionsReveromycin A administration in osteoprotegerin-deficient knockout mice inhibited bone resorption and normalized bone formation. As a result, normal bone turnover was obtained.
Journal: American Journal of Orthodontics and Dentofacial Orthopedics - Volume 144, Issue 3, September 2013, Pages 368–380