Evaluation of catch-up growth from orthodontic treatment and supplemental growth hormone therapy by using Z-scores

Pituitary dwarfism causes short stature due to partial or complete inhibition of growth hormone (GH) secretion. Supplemental therapy with human GH (rhGH) accelerates the statural growth of patients, but there is limited information about its effects on craniofacial growth. This study describes the orthodontic treatment of 2 patients (a boy and a girl) diagnosed with pituitary dwarfism and treated with rhGH therapy. Growing children have different growth velocities depending on age and sex, and this complicates the assessment of treatment effects; therefore, we used the Z-score to evaluate changes in stature and craniofacial components. Growth in craniofacial structures and stature were both enhanced by rhGH therapy during orthodontic treatment.